The Faculty

Erin Adams

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Research: Immunology, t-cell receptor, molecular recognition, signaling, membrane channels

Demet Araç-Özkan

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Research: Understanding the structural and functional basis of adhesion in the brain

Research: We use combined expertise from physics, genomics, molecular biology and materials science to study complex biological systems with single cell resolution, at very high throughput, and in context of their native environments

Sliman Bensmaia

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Research: Neural coding and the neural basis of perception

Pancho Bezanilla

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Research: Structure-function relation in voltage dependent membrane proteins

Eugene Chang

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Research: Host-microbial interactions of the intestine signals/pathways that are involved in maintaining intestinal homeostasis

Mengjie Chen

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Research: Our research group develop computational and statistical tools to address the challenges high-throughput genomics technologies have posed for data analysis and interpretation, particularly for data emerging from biomedical studies

Nicolas Chevrier

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Research: We develop interdisciplinary approaches and tools to study how the immune system functions across biological scales ranging from individual molecules and cells, to tissues, to a mammalian organism.

Sarah Cobey

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Research: Evolution of B cells, RNA viruses, epidemic dynamics, and vaccine design

Maureen Coleman

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Research: Microbial evolution and ecology, biogeochemistry

Juan de Pablo

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Research: Thermophysical properties of fluids and solids at a molecular level

Bryan Dickinson

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Research: Protein engineering, molecular evolution, metabolic regulation, chemical biology

Aaron Dinner

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Research: Modeling gene regulation and repair

D. Allan Drummond

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Research: Function and molecular basis of rapid, reversible assembly of proteins and RNA into massive heterogeneous structures in response to cellular stress

Greg Engel

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Research: Photosynthetic energy transfer, Photochemical dynamics, quantum effects in biology, ultrafast spectroscopy

Aaron Esser-Kahn

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Research: We use tools that live at the intersection of chemistry, biology, and material science to answer unique questions across different fields

Yun Fang

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Research: Research foci are mechano-transduction mechanisms by which cells sense and convert environmental mechanical stimuli into biological signaling and novel nanomedicine approaches that target dysregulated mechano-sensing pathways

Jingyi Fei

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Research: Single-molecule fluorescence imaging and quantitative biology of RNA

Andrew Ferguson

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Research: We use tools from theory, computation, data science, and machine learning to understand macromolecular folding, engineer self-assembling colloids and peptides, and design antiviral therapies

Margaret Gardel

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Research: Cytoskeletal dynamics and mechanics, cellular mechanotransduction, physics of biopolymer networks, cell adhesion and migration

Ben Glick

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Research: Dynamics of membrane domains; directed evolution of fluorescent proteins

Michael Glotzer

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Research: Determining the mechanism of cytokinesis using genetics, biochemistry, and live cell imaging

Jean T. Greenberg

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Research: Induced systemic resistance, plant immunity, Posttranslational Modifications, Pseudomonas syringae, systemic acquired resistance, type III pathogen effector

Chuan He

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Research: DNA repair, metalloregulation, suppression of virulence in pathogens

Xin He

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Research: Computational analysis and method development in human genetics and genomics

Sally Horne-Badovinac

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Research: We use genetic, cell biological and quantitative live imaging approaches to investigate how organs take on their unique shapes during development

Jun Huang

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Research: T-cell recognition, the immunosuppression of regulatory T-cells, the immune regulation of NK cells, and single-cell systems immunology

Bana Jabri

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Research: Triggers of celiac disease and immune disorders

Robert Keenan

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Research: Mechanisms of membrane protein biogenesis and quality control

Andrew Koh

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Research: Understanding the design principles in immune development that allow flexibility in cellular fate and function

Tony Kossiakoff

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Research: Structure and function of hormone-receptor interactions, enzyme-inhibitor interfaces, and synthetic proteins

David Kovar

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Research: Mechanisms of actin assembly: Real-time observation of recapitulated cytoskeleton structures by single filament microscopy

Yamuna Krishnan

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Research: Synthetic Biology, DNA nanodevices, DNA-based nanomachines, microRNA biogenesis, functional bioimaging

Stephen Kron

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Research: Cell cycle, checkpoint and signaling pathways in yeast. Novel methods for functional biochips

Ka Yee Lee

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Research: Membrane, Lipid-protein interactions, Lung surfactant, Alzheimer’s amyloid-beta peptide, Antimicrobial peptides

Jason MacLean

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Research: Observational and theoretical approaches to how the brain encodes and stores information

Peter Maurer

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Research: We develop novel quantum sensing and imaging modalities and apply them to biological systems that cannot be studied by conventional techniques. Employed tools include: Quantum Optics, Coherent Control of Spin Systems and Single-Molecule Biophysics

Juan Mendoza

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Research: Understanding basic principles of protein function relevant to human health and disease

Raymond Moellering

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Research: The group focus is on development of new chemical tools and technologies to study complexity and dynamics in the proteome, thus enabling targeted manipulation of protein targets and the pathways they govern

Edwin Munro

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Research: How the dynamics of embryonic cell and tissue behavior emerge through the interplay between regulatory biochemistry, cytoskeletal dynamics and cytomechanics

Arvind Murugan

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Research: Quantitative biology, materials design, non-equilibrium dynamics, disordered systems, and theoretical computer science

Engin Özkan

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Research: Biochemical basis of nervous system development, synaptogenesis and neural wiring; Protein-protein interaction discovery and structural biology of extracellular proteins

Stephanie Palmer

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Research: How populations of neurons collectively encode information present in their inputs and how they perform computations on these signals

Tao Pan

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Research: RNA genomics, RNA folding

Alexander Pearson

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Eduardo Perozo

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Research: Ion channels, membrane transport, membrane protein dynamics, energy transduction mechanisms, voltage dependent processes. Over-expression of membrane proteins

Joseph Piccirilli

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Research: Chemistry of RNA splicing and catalysis

David Pincus

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Research: Cell regulation of stress response pathways to maintain homeostasis as environmental conditions change

Luka Pocivavsek

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Research: We study the geometry and biomechanics of surgical anatomies and biological interfaces. Projects include aortic fragility, seal zone stability between graft stents and the aortic wall, stress focusing phenomena induced by surgical interventions, adhesion and renewal of surfaces, and the wrinkling, folding, and collapse beha

Rama Ranganathan

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Research: We use a combination of statistical genomics, biochemistry, genetics in several model organisms, structural biology, and physical theory to understand the evolutionary design of proteins and macromolecular complexes.

Phoebe Rice

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Research: Structural biochemistry of DNA recombination

Samantha Riesenfeld

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Research: Using high-throughput genomic data, the Riesenfeld Group develops approaches to computationally infer the circuits that regulate gene expression and cellular function

Ronald Rock

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Research: Myosin molecular motors, single-molecule enzymology, actin cytoskeletal dynamics

Benoît Roux

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Research: Molecular dynamics simulations, ion channels, permeation, gating, lipid membranes, crystallography, Solvation, electrostatics, Poisson-Boltzmann theory, statistical mechanics, free energy perturbation, ligand binding

Michael Rust

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Research: Connect biochemical measurements, the development of novel biophysical assays, and mathematical modeling to build a comprehensive understanding of the function of bimolecular circuits

Andrey Rzhetsky

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Research: Computational analysis of complex human phenotypes in context of changes and perturbations of underlying molecular networks

Norbert Scherer

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Research: Dynamics of macromolecular function and structure formation, equilibrium and non-equilibrium single molecule dynamics, pointillist and super-resolution nonlinear optical microscopies

Tobin Sosnick

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Research: Protein & RNA folding, design & function, simulations & predictions

Allison Squires

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Research: Allison Squires’s research interests center on manipulating, measuring, and understanding the properties and behavior of single molecules

Matthew Stephens

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Research: Bayesian and computational statistics, particularly when applied to problems in population genetics

Melody Swartz

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Research: The regulatory biology of lymphatic function

Wei-Jen Tang

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Research: Structural basis of cell signal transduction and its application to human health

Weixin Tang

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Research: Cellular recording and lineage tracing enabled by the CRISPR technology

Savas Tay

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Research: We want to understand how life works from an engineer’s perspective and to model living systems to predict their behavior. We develop highly sensitive, quantitative, and high-throughput single-cell analysis technologies to enable this quest.

The Graduate Program in Biophysical Sciences

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